hrp0089p2-p008 | Adrenals and HPA Axis P2 | ESPE2018

Testing Antiandrogens and Aromatase Inhibitors to Achieve Normal Growth in Children with Classical Congenital Adrenal Hyperplasia: A Systematic Review and Meta-analysis

Al Balwi Rana , Al Madani Wedad , Saad Rania , Ferwana Mazen

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is an autosomal recessive disease in which adrenal synthesis of glucocorticoids and mineralocorticoids is impaired and steroid biosynthesis is directed toward the formation of excessive androgens. Persistently high androgens will accelerate bone maturation and reduce final adult height.Objectives: To assess the efficacy of androgen antagonist Flutamide and aromatase inhibitor Tastolact...